Incisional Hernia with Loss of Domain as a Consequence of Botulinum Toxin a and the Covid-19 Pandemic

Introduction: Abdominal wall surgery has been one of the major victims of the COVID-19 pandemic, with a large number of patients who have seen their surgery delayed and many are still waiting to be operated on today. On the other hand, botulinum toxin is one of the main protagonists in optimizing abdominal wall surgery, especially important in complex hernia, but we must not forget that it can have adverse effects. Case report: We present the case of a 54-year-old man with a history of obesity, diabetes, hypertension, chronic renal failure and kidney transplant in 2000, who presented a midline incisional hernia as a result of an epigastric hernia operated on in 2006 and subsequently two onlay permanent synthetic mesh in 2010 and 2015. In February 2020 he presented an incisional hernia M2-4W3R3 with a volume of 35%, botox was infiltrated as optimization for surgery and while awaiting placement of a pneumoperitoneum catheter, the surgery was suspended due to the COVID-19 situation. He returns to our clinics in 2022 with a growth of the hernia and a volume of 95%. Weight loss, botulinum toxin and preoperative pneumoperitoneum were indicated. We performed a reconstruction of the abdominal wall with bilateral transversus abdominal release and preperitoneal 45x60cm polyvinylidene fluoride mesh and abdominoplasty. Discussion(s): Botulinum toxin can facilitate abdominal surgery, especially in complex hernias, but we must not forget that blocking the abdominal muscles can have adverse effects. The COVID-19 pandemic has been especially hard on surgical waiting lists, delaying surgeries and aggravating pathologies.

Business intelligence for the visualization and data analysis of Telepharmacy activity indicators in a hospital pharmacy service scorecard

Objective: The consolidation of Telepharmacy during the COVID-19 pandemic has raised the need for managing large volumes of real-time activity data through data analysis. The aim of this project was to design a dynamic, user-friendly, customizable scorecard in a hospital pharmacy service for the visualization and analysis of Telepharmacy activity indicators through the use of advanced business intelligence technology. Method: The software tool was developed by a multidisciplinary team between April and May 2021, driven from the hospital pharmacy service. Once the Telepharmacy indicators of interest were established, datasets were extracted from raw databases (administrative databases, Telepharmacy database, outpatient dispensing software, drug catalogues) through data analysis. The different data sources were integrated in a scorecard using PowerBI®. The criteria for processing missing and duplicated data were defined, and data pre-processing, normalization and transformation were performed. Once the pilot scorecard was validated by different profiles of users, the structure was designed for the panels to automatically update as databases were updated. Results: Design and implementation of a scorecard of Telepharmacy activity: general descriptive panel (demographic profile of patients, count and delivery conditions, program and medical service);geolocation of destination;pharmacological profile;relative analysis of patients involved in the Telepharmacy program with respect to the total of outpatients. In the last updating as of January 2022, data from 16, 000 dispensations to more than 4, 000 patients had been collected. This means that 21.93% of outpatients had benefited at some time point from the Telepharmacy service. Filters enable the visualization of timeline progress and patient characterization, and measure Telepharmacy activity by program. Conclusions: The processing of large Telemedicine datasets from various sources through Business Intelligence in a hospital pharmacy service makes it possible to synthesize information, generate customized reports, and visualize information in a dynamic and attractive format. The application of this new technology will help us improve strategic clinical and management decision making. © 2022 Grupo Aula Medica S.L.. All rights reserved.

Adverse drug reactions of the SARS-CoV-2 mRNA-1273 vaccine in a cohort of cancer patients of a tertiary hospital in Madrid, Spain

Background: SARS-CoV-2 vaccines efficacy and safety have been tested in phase 3 studies which did not include cancer patients. Information is scarce regarding COVID-19 vaccines safety in this population. Methods: The objective of this study is to evaluate the safety profile of the mRNA-1273 vaccine across cancer patients and its relationship to patients' demographics. This cross sectional study included patients 18-years or older with solid malignancies receiving active treatment in Hospital Clínico San Carlos (Madrid, Spain) who had received the three dose schedule of the mRNA9 1273 vaccine. Patient electronic medical records were reviewed retrospectively to collect data between April 19, 2021 and December 31, 2021. Patients with documented previous infection by SARS-Cov-2 were excluded. Results: 93 patients met inclusion criteria. 31 patients (33%) were male and 62 patients (66%) were female. Mean age was 61 [SD 8]. 33% of the study population had metastatic disease. The majority of patients (60%) had ECOG 0 whereas 32% and 8% of the population had ECOG 1 and 2 respectively. Most common tumors were breast (33%) and gastrointestinal (17%). Treatment modalities included chemotherapy (37%), targeted therapy (23%), immunotherapy (12%) and combined therapy (28%). Local adverse effects at the site of injection and systemic adverse reactions had different trends, local adverse reactions were reported more frequently after the first and second dose than after the third (42%, 50% and 36% respectively), while systemic adverse reactions were reported less frequently after the first and second dose than after the third (16%, 35% and 53% respectively). Most common systemic adverse effect was fever followed by malaise and myalgia. No grade 4 or 5 adverse events were reported. We found a statistically significant association between sex and systemic adverse reactions after the third dose with a moderate correlation assessed by Cramer's V. Cochran-Armitage test showed a statistically significant linear trend, p = 0.012, with higher ECOG score associated with a lower proportion of patients suffering from systemic side effects. A logistic regression showed that females had 5.79 times higher odds to exhibit systemic adverse events after the third dose (p = 0.01) compared to males. Increasing age was associated with a decreased likelihood of exhibiting adverse events (p = 0.016). ECOG scores didn't show a statistically significant association. Conclusions: mRNA-1273 vaccine shows a tolerable safety profile, which is similar to the non-oncologic population. The likelihood of adverse reactions appears to be associated with gender and age. Its association with ECOG scores is less evident. Further studies are needed to elucidate the safety profile of COVID-19 vaccines in cancer patients.

[Observational study of the adherence to the correct use of face masks by the general population in open public places during two periods of the COVID-19 pandemic in four Spanish cities.]

OBJECTIVE: One of the steps adopted to mitigate the pandemic due to SARS-CoV-2 is the use of face masks by the general population. For a face mask to be effective it should cover the nose and the mouth. We wanted to measure the correct use of the face mask by the general population in open public spaces through direct observation. METHODS: We conducted an observational study of the proper use of face masks among the general population in open public places in Bilbao, Santander, Oviedo and Zaragoza from 16th to 26th July, 2020 and from 23rd January to 2nd March, 2021. Sampling for convenience;compliance of the proper use of a mask was evaluated when adults completely covered their mouth and nose. The type of mask and its improper use was registered using a standardized form. The results were obtained using frequency distribution, Pearson's chi-squared test and multivariate logistic regression analysis. RESULTS: A total of 5,464 observations were documented. The overall compliance was 89.5%. We observed that the compliance in 2021 (94.7%) was 10.9 percentage points higher than in 2020 (83.8%) (p<0.001). The main cause of non-compliance was the incorrect placement of face masks (64%);36% were without masks. The non-reusable face masks were most commonly worn (54.1%). We observed a significant increase in use of high-efficiency face masks in 2021 (27.1%) versus 2020 (13.7%). CONCLUSIONS: In all the cities where the study was conducted we observed an increase in compliance of the proper use of face masks as well as an increased usage of high-efficiency masks. The main cause of non-compliance was incorrect placement.

Developing Data Literacy Competences at University: the experience of the DEDALUS project

Nowadays, data are everywhere becoming more and more important in everyday life. Recently, during the COVID-19 outbreak, data are being used on a massive scale, and having the skills to understand the information conveyed through numbers, percentages and trends curves became essential. From this perspective, data literacy is a competence not only important for those operating in computer science or technological sectors, but it is acquiring a key role in other sectors such as social science, humanities, and journalism. In this paper, we present the DEDALUS project, an EU-funded project aimed at developing data literacy courses for university students. DEDALUS defined a competence framework that identifies a set of competences related to data literacy, to which modular university courses in different disciplines are based upon. The outcomes of the project were piloted in 5 European countries in order to define the implementation strategies that identifies different models of data literacy inclusion in the higher education domain.

Observational study of the adherence to the correct use of face masks by the general population in open public places during two periods of the COVID-19 pandemic in four Spanish cities

Background: One of the steps adopted to mitigate the pandemic due to SARS-CoV-2 is the use of face masks by the general population. For a face mask to be effective it should cover the nose and the mouth. We wanted to measure the correct use of the face mask by the general population in open public spaces through direct observation. Methods: We conducted an observational study of the proper use of face masks among the general population in open public places in Bilbao, Santander, Oviedo and Zaragoza from 16th to 26th July, 2020 and from 23rd January to 2nd March, 2021. Sampling for convenience;compliance of the proper use of a mask was evaluated when adults completely covered their mouth and nose. The type of mask and its improper use was registered using a standardized form. The results were obtained using frequency distribution, Pearson's chi-squared test and multivariate logistic regression analysis. Results: A total of 5,464 observations were documented. The overall compliance was 89.5%. We observed that the compliance in 2021 (94.7%) was 10.9 percentage points higher than in 2020 (83.8%) (p<0.001). The main cause of non-compliance was the incorrect placement of face masks (64%);36% were without masks. The nonreusable face masks were most commonly worn (54.1%). We observed a significant increase in use of high-efficiency face masks in 2021 (27.1%) versus 2020 (13.7%). Conclusions: In all the cities where the study was conducted we observed an increase in compliance of the proper use of face masks as well as an increased usage of high-efficiency masks. The main cause of non-compliance was incorrect placement.

Agriculture 4.0: An Implementation Framework for Food Security Attainment in Nigeria's Post-Covid-19 Era

The challenge of Nigeria's food insecurity in the era of the Covid-19 pandemic, insecurity, climate change, population growth, food wastage, etc., is a demanding task. This study addresses Nigeria's food insecurity challenges by adopting agriculture 4.0 and commercial farming. Using data from six digital libraries, the Nigerian Bureau of Statistics, and other internet sources, we conducted a Systematic Literature Review (SLR using PRISMA) on Nigeria's agriculture, food security, and agriculture 4.0. Our results show Nigeria's current agricultural state, threats to food security, and modern digital agriculture technologies. We adapted our SLR findings to develop an implementation framework for agriculture 4.0 in solving Nigeria's food insecurity challenge in the post-Covid-19 era. Our proposed framework integrates precision agriculture in Nigeria's food production and the necessary enabling digital technologies in the agri-food supply chain. We analyzed the critical implementation considerations during each agri-food supply chain stage of farming inputs, farming scale, farming approach, farming operation, food processing, food preservation/storage, distribution/logistics, and the final consumers. This study will help researchers, investors, and the government address food security in Nigeria. The implementation of agriculture 4.0 will substantially contribute to SDG 2 (zero hunger), SDG 3 (good health and well-being), and SDG 8 (decent work and economic growth) of #Envision 2030 of the United Nations, for the benefit of Nigeria, Africa, and the entire world.

Pulmonary embolisms in patients with COVID-19: a prevalence study in a tertiary hospital. / Tromboembolismo pulmonar en pacientes con COVID-19: estudio de prevalencia en un hospital terciario.

INTRODUCTION: SARS-CoV-2, the virus responsible for the current pandemic, predominantly affects the respiratory tract, and a growing number of publications report the predisposition of patients with COVID-19 to develop thrombotic phenomena. OBJECTIVE: To determine the prevalence of pulmonary embolism in patients with COVID-19; to determine the possible relationship between the severity of pulmonary involvement and D-dimer levels; to analyze the location of pulmonary embolisms in patients with COVID-19 and to compare it with the location in patients without COVID-19. METHODS: This retrospective study analyzed all CT angiograms of the pulmonary arteries done in patients with suspected pulmonary embolisms between March 15 and April 30, 2020 and compared them with studies done in the same period one year earlier. RESULTS: We included 492 pulmonary CT angiograms (342 (69.9%) in patients with COVID-19 and 147 (30.1%) in patients without COVID-19). The prevalence of pulmonary embolisms was higher in patients with COVID-19 (26% vs. 16.3% in patients without COVID-19, p=0.0197; relative risk=1.6). The prevalence of pulmonary embolisms in the same period in 2019 was 13.2%, similar to that of the group of COVID-19-negative patients in 2020 (p=0.43). There were no significant differences in D-dimer levels or the location of pulmonary embolisms between the two groups. CT showed moderate or severe pulmonary involvement in 78.7% of the patients with COVID-19. CONCLUSIONS: Patients with COVID-19 have an increased prevalence of pulmonary embolisms (26%), and most (78.7%) have moderate or severe lung involvement on CT studies. The location of pulmonary embolisms and the degree of elevation of D-dimer levels does not differ between patients with COVID-19 and those without.

Radiologic diagnosis of patients with COVID-19. / Diagnóstico radiológico del paciente con COVID-19.

The pandemia caused by the SARS-CoV-2 virus has triggered an unprecedented health and economic crisis. Although the diagnosis of infection with SARS-CoV-2 is microbiological, imaging techniques play an important role in supporting the diagnosis, grading the severity of disease, guiding treatment, detecting complications, and evaluating the response to treatment. The lungs are the main organ involved, and chest X-rays, whether obtained in conventional X-ray suites or with portable units, are the first-line imaging test because they are widely available and economical. Chest CT is more sensitive than plain chest X-rays, and CT studies make it possible to identify complications in addition to pulmonary involvement, as well as to suggestive alternative diagnoses. The most common radiologic findings in COVID-19 are airspace opacities (consolidations and/or ground-glass opacities), which are typically bilateral, peripheral, and located primarily in the lower fields.